All You Need to Know about Ionamin Usage, Drug Interactions, and Side Effects

Ionamin is an appetite suppressant that is commonly used by obese people to lose weight quickly. Considered the last resort before weight loss surgery, the diet pill contains 37.5mg of phentermine, a sympathomimetic that is analogous to amphetamine, making it impossible to acquire over the counter legally and without a prescription in most countries. In the United States, it is considered a Schedule IV Controlled Substance that cannot be purchased without a doctor’s prescription.

Ionamin is also known by the generic name phentermine resin.  When used correctly and together with the recommended exercise quota and dietary changes, it can lead to significant weight loss within months.

Ionamin works by directly affecting the functioning of the CNS in order to achieve its appetite-suppressing functions. Although the brand name was discontinued following health concerns, the drug still exists primarily in its generic version.

Consumption of the stimulant results in significant side effects and in rare cases, a drug dependency might arise. It is, therefore, advisable that you do not share your medication with anyone and that you do not self-medicate with Ionamin or any other phentermine-based dietary supplements.


Ionamin medication is taken orally once a day as prescribed by the doctor. Ideally, the patient should take it at least 1 hour before breakfast or 1-2 hours afterward. For patients who can’t handle the dosage as it is, the doctor may adjust it slightly to suit their preferences. Alternatively, Ionamin can be taken in two half-pill doses of 18.75mg per day.

Ionamin should not be taken 10 to 14 hours before bedtime since it may cause restlessness or insomnia. For sustained-release capsules, it is advisable that you swallow it whole. Crushing it may cause the side effects to be increased.

If you miss a dose, take it immediately you remember unless it is almost time for your next dose, in which case you should skip it.

Ionamin should only be taken in intermittent periods of a few weeks at a time. The longer it is used, the higher the risk of getting serious side effects is. The medication may also have withdrawal symptoms. Therefore, it is not advisable to abruptly stop taking the medication without the doctor’s consent as this will cause serious withdrawal reactions. Your doctor is capable of gradually tapering off your dose to avoid this.

Do not take more or less of Ionamin than is prescribed. It is associated with addictive behaviors that may become more serious with a prolonged consumption of the drug.


Ionamin should NOT be taken under the following circumstances:

· If you’re allergic to sympathomimetic amines such as decongestants and other stimulants, Ionamin may have ingredients that could cause a serious allergic reaction. Alert your doctor to any allergies you may have to the drug beforehand.

· If you have a history of unmanaged high blood pressure, heart diseases, mood disorders such as depression and anxiety, bipolar, mental disorders such as schizophrenia, hyperthyroidism, and pulmonary hypertension.

· If you’re diabetic, under high blood pressure medication, if you suffer from heart conditions such as arrhythmia, if you experience seizures, or if you have a pre-existing kidney disease.

· If you have phenylketonuria (PKU) and are required to avoid aspartame or limit it in your diet.

· If you’re a pregnant or breastfeeding mother; Ionamin can harm an unborn baby and can also be passed from mother to infant through breast milk.

When you use Ionamin:

· Do not drive or operate heavy machinery because the medication can induce dizziness and in some cases, drowsiness.

· Consider the fact that kidney functions deteriorate with age and as such, elderly individuals may feel the side effects more adversely.

· Alert your doctor before surgery that you’re on the medication

· Steer clear of any alcoholic beverages.

Drug Interactions

Ionamin should not be used alongside certain medications since it may result in some serious interactions. Alert your doctor to any drugs you may be taking beforehand. Once your Ionamin treatment is underway, do not start or abruptly stop taking any medication without consulting your doctor.

Ionamine may react adversely with the following drugs:

· MAO inhibitors – Taking this medication with MAO inhibitors may result in a possibly fatal drug interaction. Ensure you have not consumed any MAO inhibitors two weeks prior to the start of your dosage.

· Depression medication (TCAs), SSRIs, SNRIs, high blood pressure medication (guanethidine and methyldopa), phenothiazines, stimulants such as amphetamines, and recreational drugs such as cocaine and ecstasy.

· Medication that induces drowsiness such as anti-seizure drugs, narcotic painkillers, psychiatric medication, sleep medication, and certain antihistamines (diphenhydramine).

· Caffeine – Too much caffeine will cause a more prominent manifestation of the side effects of Ionamin. Cut down your caffeine intake (tea, coffee, sodas) to avoid an increase in the side effects of Ionamin.

Side Effects

Common side effects of Ionamin include the following:

· Nausea.

· Vomiting.

· Dizziness.

· Dryness in the mouth.

· Constipation.

· Diarrhea.

· Insomnia.

These are often experienced during the course of medication and should not be cause for alarm unless experienced with too much intensity or frequency. In some instances, one may experience the following side effects:

· A fluctuating interest in sex.

· Inexplicable mood changes.

· Nervousness.

· Involuntary muscle movement.

· Hallucinations.

· Irregular heartbeats.

In the event of these side effects, it is advisable to consult your doctor immediately in order to understand why you may be experiencing them. Serious side effects such as the following may arise due to prolonged periods of taking the medication:

· Slurred speech.

· Recurrent headaches.

· Weakness in areas of the body.

· Blurred vision.

· Seizures.

· Pulmonary hypertension.

· Inexplicable feelings of happiness.

· Swollen ankles and feet.

· Fainting.

· Overexertion.

· Chest pains.

· Difficulty breathing after mild exertion.

If you experience any of the aforementioned side effects, stop taking Ionamin and seek medical assistance immediately. If you’re unaware whether you’re allergic to Ionamin and/or any of its ingredients, call your doctor immediately when you start to experience symptoms such as:

· Tightening of the chest/difficulty breathing.

· Dizziness and fainting.

· Rashes.

· Itchiness around the tongue and throat.

This could mean that you’re having an allergic reaction to Ionamin or one of the inactive ingredients contained inside the medication. You should stop taking it immediately and seek emergency medical attention as you may be having a severe allergic reaction to the medication.

This list does not cover all the possible side effects one may experience when taking Ionamin. In case of you experience side effects that are not listed herein, contact your doctor immediately.